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Dual targeting hyaluronic acid - RGD mesoporous silica coated gold nanorods for chemo-photothermal cancer therapy

文献作者：Huimin Zhou, Haixing Xu, Xin Li, Yahui Lv, Tian Ma, Shiying Guo, Zhijun Huang, Xiaobing Wang, Peihu Xu  《Materials Science and Engineering: C》

ABSTRACTS
This work reports a multifunctional nanoplatform (GNRs@mSiO2-HA-RGD) by conjugating targeting ligand hyaluronic acid (HA) and RGD with mesoporous silica-coated gold nanorods (GNRs@mSiO2) for dual-targeted chemo-photothermal therapy. Doxorubicin hydrochloride (DOX) was used as the model drug to investigate the drug loading, in vitro drug release profiles and cell evaluation. The nanoplatform has demonstrated a good photothermal effect and excellent drug loading capacity of about 20.16%. It also had pH-enzyme sensitive and NIR-triggered drug release properties. Cellular uptake experiment results indicated that DOX-GNRs@mSiO2-HA-RGD can be dual-targeted to ovarian cancer cells via CD44 and integrin receptor mediated endocytosis pathway. Cytotoxicity experiments demonstrated that combined therapy exhibited a better therapy effect compared to that of single chemotherapy or photothermal therapy. Our study demonstrates that DOX-GNRs@mSiO2-HA-RGD may be a new promising dual-targeted delivery system for chemo-photothermal therapy.
KEY WORDS
Hyaluronic acid; RGD peptide; Dual-targeting; Mesoporous silica coated gold nanorods; Photothermal therapy; Chemotherapy.
SCREENSHOT


RELATED PRODUCTS
CGRGDSY was purchased from China Peptides Co., Ltd. (Shanghai, China). 
CHAINING
https://www.sciencedirect.com/science/article/pii/S0928493117321379
Number of Residues:7
1-Letter Code:CGRGDSY
3-Letter Code:Cys-Gly-Arg-Gly-Asp-Ser-Tyr

Molecular weight (Mr):756.79 g/mol
Isoelectric point:6.2
Net charge at pH 7.0:0.0
Average hydrophilicity:0.4
Ratio of hydrophilic residues / total number of residues:43 %
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