Author：Ning Xia, Dehua Deng, Yiru Wang, Chao Fang, and Su-Juan Li 《International Journal of Nanomedicine》 ABSTRACTS Background Prostate-specific antigen (PSA), a serine protease, is a biomarker for preoperative diagnosis and screening of prostate cancer and monitoring of its posttreatment. Methods In this work, we reported a colorimetric method for clinical detection of PSA using gold nanoparticles (AuNPs) as the reporters. The method is based on ascorbic acid (AA)-induced in situ formation of AuNPs and Cu 2+ -catalyzed oxidation of AA. Specifically, HAuCl 4 can be reduced into AuNPs by AA; Cu 2+ ion can catalyze the oxidation of AA by O 2 to inhibit the formation of AuNPs. In the presence of the PSA-specific peptide (DA H SSKLQLAPP)-modified gold-coated magnetic microbeads (MMBs; denoted as DA H SSKLQLAPP-MMBs), complexation of Cu 2+ by the MMBs through the DAH–Cu 2+ interaction depressed the catalyzed oxidation o...
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