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CAS:131602-53-4|Amyloid beta-Protein (25-35)|GSNKGAIIGLM

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β-Amyloid (25-35)
GSNKGAIIGLM
Number of Residues:11
1-Letter Code:GSNKGAIIGLM
3-Letter Code:Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met

Molecular weight (Mr):1060.28 g/mol
Isoelectric point:10.1
Net charge at pH 7.0:1.0
Average hydrophilicity:-0.3
Ratio of hydrophilic residues / total number of residues:27 %


NameAmyloid beta-Protein (25-35)
Code[131602-53-4]
The aliasAmyloid beta-Protein (25-35)
Sequence (single letter abbreviation)GSNKGAIIGLM
Sequence (three-letter abbreviation)H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH (trifluoroacetate salt)
A basic descriptionThis peptide was isolated from the insoluble core of Alzheimer's disease (AD) amyloid plaque. It is the fragment (61-95) of NACP or alpha-synuclein and forms amyloid fibrils via a nucleation-dependent polymerization mechanism. Accumulation of NAC aggregates in the synapse might be responsible for the neurodegeneration in AD and in the prion diseases.
solubility
The molecular weight1060.28
Chemical formulaC45H81N13O14S1
The purity80%，90%，95%，98%，99%
Weight1mg,5mg,10mg,50mg,100mg,1g
Storage conditionsStore at -20°C. Keep tightly closed. Store in a cool dry place.
Annotation
Documents
Figures
ReferenceB.A.Yankner et al., Science, 250, 279 (1990) A.Klegeris et al., Biochem. Biophys. Res. Commun., 199, 984 (1994) C.J.Pike et al., Neuroscience, 63, 517 (1994) C.J.Pike et al., J. Neurochem., 64, 253 (1995) J.H.Ippel et al., Proc. Natl. Acad. Sci. USA, 99, 8648 (2002) M.E.Clementi et al., FEBS Lett., 579, 2913 (2005) F.Misiti et al., Neurochem. Int., 46, 575 (2005) G.Wei and J.-E.Shea, Biophys. J., 91, 1638 (2006) D.Buntup et al., Neurochem. Res., 33, 248 (2008) I.D.Limon et al., Neurosci. Res., 63, 129 (2009) L.Millucci et al., Curr. Protein Pept. Sci., 11, 54 (2010) H.-H.G.Tsai et al., Proteins, 78, 1909 (2010)
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