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ONX-0914, a selective inhibitor of immunoproteasome, ameliorates experimental autoimmune myasthenia gravis by modulating humoral response

Author：Ru-Tao Liu, Peng Zhang, Chun-Lin Yang, Yu Pang, Min Zhang, Na Zhang, Long-Tao Yue, Xiao-Li Li, Heng Li, Rui-Sheng Duan   《Journal of Neuroimmunology》

ABSTRACTS
Accumulating evidence shows that the immunoproteasome participates in the immune response, beyond its initial role in the protein degradation. Here, we tested the effects of the selective immunoproteasome inhibitor, ONX-0914, on experimental autoimmune myasthenia gravis (EAMG). We found that ONX-0914 ameliorated the severity of ongoing EAMG by reducing the autoantibody affinity, accompanied with decreased Tfh cells and antigen presenting cells. Also it reduced the percentage of Th17 cells and inhibited the secretion of IL-17. Our data indicated ONX-0914 may bring benefit for MG therapy.

Graphical abstract




KEY WORDS
ONX-0914; Immunoproteasome; Experimental autoimmune myasthenia gravis; Humoral immunity
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R97-116 peptide (DGDFAIVKFTKVLLDYTGHI) was synthesized by ChinaPeptides Corporation (Shanghai, China).
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https://www.sciencedirect.com/science/article/pii/S0165572817301820

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