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Efficient siRNA transfer to knockdown a placenta specific lncRNA using RGD-modified nano-liposome: A new preeclampsia-like mouse model

Author：Qianwen Yu, Yue Qiu, Xuhui Wang, Jiajing Tang, Yayuan Liu, Ling Mei, Man Li, Ming Yang, Li Tang, Huile Gao, Zhirong Zhang, Wenming Xu, Qin He   《International Journal of Pharmaceutics》

ABSTRACTS
Preeclampsia is one of the most serious pregnancy complications. Many animal models have already been developed by researchers to study the pathogenesis and treatment of preeclampsia. However, most of these animal models were established by systemic administration or by surgery in the uterine cavity, which could lead to unwanted systemic toxicity or operative wounds and affect the accuracy of the results.

Graphical abstract



KEY WORDS
Placenta targeting; siRNA transfer; Preeclampsia; RGD peptide; Animal model
SCREENSHOT

RELATED PRODUCTS
 Cyclic RGD peptide with a terminal cysteine, c (RGDfK)-Cys, cysteine conjugated to the branch of lysine, was purchased from China peptides Co. Ltd. (Shanghai, China).
CHAINING
https://www.sciencedirect.com/science/article/pii/S0378517318303004
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